The Losers are an elite black ops team of United States Special Forces operatives, led by Clay (Jeffrey Dean Morgan) and formed by Roque (Idris Elba), Pooch (Columbus Short), Jensen (Chris Evans), and Cougar (Óscar Jaenada), who are sent to Bolivia in a search and destroy mission on a compound run by a drug lord. While painting a target for an upcoming air strike, the Losers spot slave children in the compound and try to call off the attack, but their superior, codenamed "Max" (Jason Patric), ignores their pleas. With no other option, the Losers enter the compound, successfully rescue the children and kill the drug lord in the process. As a helicopter arrives to pick them up, Max, convinced that they know too much, orders it to be destroyed, unaware that they decided to rescue the children first. The Losers watch as a missile destroys the helicopter and kills 25 innocents. Knowing that the attack was meant to kill them, they fake their deaths and become stranded in Bolivia, determined to get revenge on the mysterious Max.